Statistics play a critical role in biological and clinical research. To promote logically consistent representation and classification of statistical entities, we have developed the Ontology of Biological and Clinical Statistics (OBCS). OBCS extends the Ontology of Biomedical Investigations (OBI), an OBO Foundry ontology supported by some 20 communities. Currently, OBCS contains 686 terms, including 381 classes imported from OBI and 147 classes specific to OBCS. The goal of this paper is to present OBCS for community critique and to describe a (...) number of use cases designed to illustrate its potential applications. The OBCS project and source code are available at http://obcs.googlecode.com. (shrink)

Statistics play a critical role in biological and clinical research. However, most reports of scientific results in the published literature make it difficult for the reader to reproduce the statistical analyses performed in achieving those results because they provide inadequate documentation of the statistical tests and algorithms applied. The Ontology of Biological and Clinical Statistics (OBCS) is put forward here as a step towards solving this problem. Terms in OBCS, including ‘data collection’, ‘data transformation in statistics’, ‘data visualization’, ‘statistical data (...) analysis’, and ‘drawing a conclusion based on data’, cover the major types of statistical processes used in basic biological research and clinical outcome studies. OBCS is aligned with the Basic Formal Ontology (BFO) and extends the Ontology of Biomedical Investigations (OBI), an OBO (Open Biological and Biomedical Ontologies) Foundry ontology supported by over 20 research communities. We discuss two examples illustrating how the ontology is being applied. In the first (biological) use case, we describe how OBCS was applied to represent the high throughput microarray data analysis of immunological transcriptional profiles in human subjects vaccinated with an influenza vaccine. In the second (clinical outcomes) use case, we applied OBCS to represent the processing of electronic health care data to determine the associations between hospital staffing levels and patient mortality. Our case studies were designed to show how OBCS can be used for the consistent representation of statistical analysis pipelines under two different research paradigms. By representing statistics-related terms and their relations in a rigorous fashion, OBCS facilitates standard data analysis and integration, and supports reproducible biological and clinical research. (shrink)

The purpose of this study was to evaluate, revise, and extend the Informed Consent Ontology (ICO) for expressing clinical permissions, including reuse of residual clinical biospecimens and health data. This study followed a formative evaluation design and used a bottom-up modeling approach. Data were collected from the literature on US federal regulations and a study of clinical consent forms. Eleven federal regulations and fifteen permission-sentences from clinical consent forms were iteratively modeled to identify entities and their relationships, followed by community (...) reflection and negotiation based on a series of predetermined evaluation questions. ICO included fifty-two classes and twelve object properties necessary when modeling, demonstrating appropriateness of extending ICO for the clinical domain. Twenty-six additional classes were imported into ICO from other ontologies, and twelve new classes were recommended for development. This work addresses a critical gap in formally representing permissions clinical permissions, including reuse of residual clinical biospecimens and health data. It makes missing content available to the OBO Foundry, enabling use alongside other widely-adopted biomedical ontologies. ICO serves as a machine-interpretable and interoperable tool for responsible reuse of residual clinical biospecimens and health data at scale. (shrink)

Розкрито сутність поняття «рейтинг». Доведено значущість рейтингової оцінки для суб’єктів фінансового ринку, зокрема для страхових компаній, потенційних страхувальників, інвесторів та кредиторів.

With the increased use of Artificial Intelligence (AI) in wildlife conservation, issues around whether AI-based monitoring tools in wildlife conservation comply with standards regarding AI Ethics are on the rise. This review aims to summarise current debates and identify gaps as well as suggest future research by investigating (1) current AI Ethics and AI Ethics issues in wildlife conservation, (2) Initiatives Stakeholders in AI for wildlife conservation should consider integrating AI Ethics in wildlife conservation. We find that the existing literature (...) weakly focuses on AI Ethics and AI Ethics in wildlife conservation while at the same time ignores AI Ethics integration in AI systems for wildlife conservation. This paper formulates an ethically aligned AI system framework and discusses pre-eminent on-demand AI systems in wildlife conservation. The proposed framework uses agile software life cycle methodology to implement guidelines towards the ethical upgrade of any existing AI system or the development of any new ethically aligned AI system. The guidelines enforce, among others, the minimisation of intentional harm and bias, diversity in data collection, design compliance, auditing of all activities in the framework and ease of code inspection. This framework will inform AI developers, users, conservationists, and policymakers on what to consider when integrating AI Ethics into AI-based systems for wildlife conservation. (shrink)

This book offers a critical introduction to the work of American philosopher D. G. Leahy (1937-2014). Leahy's fundamental thinking can be characterized as an absolute creativity in which all creating is 'live' -- a happening occurring now that manifests a supersaturated polyontological actuality that is essentially created by the logic that characterizes it. Leahy leaves behind the categorial presuppositions of modern thought, eclipsing both Cartesian and Hegelian subjectivities and introducing instead an essentially new form of thinking founded in a nondual (...) logic of creation. The new thinking delineates the absolute unicity of existence as a creative interactivity beyond all traditional dichotomies (such as one vs. many, unity vs. plurality, identity vs. change): a fully "digitized" actuality that is nothing but newness, which inherently implies nothing but change. Through this new form of thinking, change itself is revealed to be the very essence of reality and mind. Any reader looking for a quantum leap beyond the thrall of modern and postmodern fixations is invited to hear and apprehend this new thinking that refuses to be conditioned by paradigms, categories, species, genera, walls, bridges, boundaries, or abstractions: an essentially free thinking that embodies creative novelty itself. (shrink)

If Spinoza is a thinker very present in the Faculties of Philosophy, on the other hand, he is presented as one of the great forgotten of the humanist programs of secondary education. Contrary to what happened with other philosophers, who had more chance of spreading in non-specialized contexts (we can cite Nietzsche, Pascal, Plato or Schopenhauer as obvious examples), Spinoza is generally considered a excessively systematic author, and complex, whose works would have been written for a small group of scholars. (...) Nothing could be further from the truth. Spinoza’s life was full of completely surprising events, from his estrangement from the Jewish community (which repudiated him in a strict and disagreeable way), through his dalliances with heterodox currents which gradually grew in power, until his meeting with Leibniz and his intrepid travels. from one part of his native Holland to another. In this article, we examine the concept of desire in Spinoza's philosophy and its connection to the philosopher's decision to find the greater good. Since the greatest good, in turn, is nothing but its own enjoyment, we conclude that ignoring its existence, seeking it, and living it are, respectively, the conditions of the vulgar, the philosopher, and the wise, as what happened in the Garden of Epicurus. (shrink)

Dans cet ouvrage, la philosophie de Rene Descartes nous apporte un discours nouveau sur le probleme relatif au rapport permanent entre la raison et la foi a partir de ses Meditations metaphysiques. Cette philosophie nous invite a nous questionner sur la necessite d un choix entre l engagement de croire et la liberte de savoir. Ce livre nous permet de mieux comprendre les enjeux d une telle problematique. Alla Marcellin Konin a partage l experience de plusieurs annees d enseignement de (...) la philosophie dans les Academies de Poitiers, de Nantes, de Caen et de Rouen en France. a l Universite de Poitiers et de Bordeaux 3, il a travaille sur la philosophie de la Nature et sur l Idealisme allemand. Mediateur dans les Organisations et Membre associe a MAPP (Metaphysique Allemande et Philosophie Pratique) de l Universite de Poitiers, il enseigne la philosophie a l Universite Felix Houphouet-Boigny de Cocody. Il poursuit actuellement ses recherches en philosophie de l histoire, en metaphysique, en philosophie morale et politique. Alla Marcellin Konin a partage l experience de plusieurs annees d enseignement de la philosophie dans les Academies de Poitiers, de Nantes, de Caen et de Rouen en France. a l Universite de Poitiers et de Bordeaux 3, il a travaille sur la philosophie de la Nature et sur l Idealisme allemand. Mediateur dans les Organisations et Membre associe a MAPP (Metaphysique Allemande et Philosophie Pratique) de l Universite de Poitiers, il enseigne la philosophie a l Universite Felix Houphouet-Boigny de Cocody. Il poursuit actuellement ses recherches en philosophie de l histoire, en metaphysique, en philosophie morale et politique.". (shrink)

La notion de conflit révèle divers aspects. Parmi les litiges, les violences, les disputes, les mésententes, les guerres, l'importance de définir les éléments de conflictualité et le caractère institutionnel des enquêtes en matière de gestion et de résolution des conflits de nos jours. Néanmoins, nous sommes parvenus à percevoir que la clé du succès des résolutions des conflits pour une paix durable réside dans l'expérience humaine de la culpabilité et du pardon. Ce n'est certes pas des éléments nouveaux pour les (...) spécialistes et les diplomates en matière de gestion des conflits. Cependant, Ces deux notions sont reléguées à un second plan au profit de compromis et de mesures coercitives à l'encontre des factions en conflits. Notre vision de la résolution des conflits est que sans l'incompréhension de l'expérience de la culpabilité et du pardon,haine durable ). Est-il possible d'institutionnaliser le pardon et de mener des actions conduisant à une véritable responsabilité collective et individuelle préalable à toute réconciliation durable des peuples? La nature et la fréquence de nos conflits obligent à revenir sur les méthodes d'approche qui viennent d'être utilisées. En effet, c'est ce que tentent de faire certaines commissions pour la réconciliation appelées pour la plupart « Dialogue – Vérité – Réconciliation ; Dialogue – Justice – Réconciliation ; justice et paix, etc. ». où les belligérants, les bourreaux et les victimes sont invités à l'aveu, à la vérité et au pardon pour un revivreensemble. Mais dans l'espace d'un processus de réconciliation engagé à travers desdites commissions, les ballets de confessions aussi bien que les sentiments de victimisation se succèdent avant à l'arrière fond l'amnistie pour les bourreaux et l'octroi du pardon de la partie des victimes. Cela, parait peu convainquant pour la raison que ces commissions sont en partie majeure installées par les vainqueurs du moment. Dans une certaine Afrique surtout, ces derniers (les vainqueurs) sont aidés par des alliés ayant atteint de hauts niveaux. Il s'agit alors de processus où la paix est provisoire et se poursuit au bout de la force ; et où les bourreaux sont toujours les autres. (shrink)

Locke is the first English philosopher to be considered in this series, and that fact of itself is worthy of attention. Philosophy, of course, like science, knows no frontiers and no national boundaries. Yet it is true to say that Locke’s contribution to philosophy is typically and peculiarly English. His moderation, his emphasis upon experience, his tolerant spirit of compromise, his dislike of mystical extravagance and of metaphysical speculation, even that elusive quality of his which people call his “common sense”, (...) are English traits. His very defects, illogicality leading to inconsistency and an awkward disorderliness of thought so abhorrent to the. (shrink)

Crop genetic resources constitute a ‘new’ global commons, characterized by multiple layers of activities of farmers, genebanks, public and private research and development organizations, and regulatory agencies operating from local to global levels. This paper presents sui generis biocultural community protocols that were developed by four communities in Benin and Madagascar to improve their ability to contribute to, and benefit from, the crop commons. The communities were motivated in part by the fact that their national governments’ had recently ratified the (...) Plant Treaty and the Nagoya Protocol, which make commitments to promoting the rights of indigenous peoples, local communities and farmers, without being prescriptive as to how Contracting Parties should implement those commitments. The communities identified the protocols as useful means to advance their interests and/or rights under both the Plant Treaty and the Nagoya Protocol to be recognized as managers of local socio-ecological systems, to access genetic resources from outside the communities, and to control others’ access to resources managed by the community. (shrink)

The Nature of God explores a perennial problem in the philosophy of religion.

pt. 1. A critique of current educational aims.--pt. 2. Reason.--pt. 3. Education and reason.

R F Dearden; Theory and Practice in Education, Journal of Philosophy of Education, Volume 14, Issue 1, 30 May 2006, Pages 17–29, https://doi.org/10.1111/j.1467-.

While it might seem prima facie plausible that divine foreknowledge is all that is needed for prophecy, this seems incorrect. To issue a prophecy, God hasto know not just how someone will act, but how someone would act were the prophecy issued. This makes some think that Middle Knowledge is required.I argue that Thomas Flint’s two Middle Knowledge based accounts of prophecy are unsatisfactory, but one of them can be repaired. However the resources needed for repair also yield a sketch (...) of a foreknowledge-only account of prophecy. (shrink)

This book is available either individually, or as part of the specially-priced Arguments of the Philosphers Collection.

This book provides a collection of sources, many of them fragmentary and previously scattered and hard to access, for the development of Peripatetic philosophy in the later Hellenistic period and the early Roman Empire. It also supplies the background against which the first commentator on Aristotle from whom extensive material survives, Alexander of Aphrodisias (fl. c. AD 200), developed his interpretations which continue to be influential even today. Many of the passages are here translated into English for the first time, (...) including the whole of the summary of Peripatetic ethics attributed to 'Arius Didymus'. (shrink)